In biological systems, the secretory pathway is a series of steps involved in secretion of a protein from a cell into the extracellular environment. It involves the journey of the protein that is destined to be secreted, from the ribosomes on the rough endoplasmic reticulum to the various compartments of the Golgi apparatus, packaged into a vesicle and finally secreted by exocytosis, via fusion with the plasma membrane. Each step in the pathway has factors determining the passage of the protein such as measures of transport regulation that signal protein location, the mechanics of proceeding further in the pathway, selection of proteins or modifications of the protein itself. Each of these factors contributes to the arrival and final structure of the secreted protein. In reference to error in the secretory pathway, there is extremely little room for any, as correct sorting and packaging is so crucial that mistakes lead to fatal and severe diseases. This essay will this outline the......

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Title: Room For Error In Secretory Pathways
Approximate Word Count: 1919
Approximate Pages: 8 (250 words per double-spaced page)

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