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Schizophrenia is a severe mental illness that afflicts approximately one percent of the world's population and yet its etiology is relatively unknown. There is a clear link between schizophrenia and genes in familial cases, demonstrated by heritability. However there is also evidence that genes contribute to the onset of schizophrenia in sporadic cases (where there is no history of the disease in the family) due to accumulating ‘de novo' mutations in ageing fathers. One experiment suggests that up to 26% of sporadic cases of schizophrenia are due to paternal age (Malaspina, Harlap, Fennig, Heiman, Nahon, Feldman & Susser, 2001). A number of studies have demonstrated an effect of paternal age on schizophrenia, and have supported the de novo mutation hypothesis to explain the maintenance of schizophrenia in the population (Malaspina et al, 2001; Byrne, Agerbo, Ewald, Eaton, Mortensen, 2003; Zammit, Allebeck, Dalman, Lundberg, Hemmingson, Owen & Lewis, 2003; Sipos, Rasmussen,...

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Title: Paternal Age And Increased Risk Of Schizophrenia, Providing Evidence For De Novo Mutations
Approximate word count: 2218
Approximate pages: 9 (250 words per double-spaced page)

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1. Paternal Age And Increased Risk Of Schizophrenia, Providing ...
   

   Paternal Age and Increased Risk of Schizophrenia, Providing Evidence for
   De Novo Mutations. Schizophrenia is a severe mental illness ...