introduction
Lung cancer remains a major cause of death worldwide with
over 1.1 million deaths per year [1]. Non-small cell lung
cancer (NSCLC) accounts for at least 80% of all lung tumours.
About 35% of these patients present with locally advanced
non-metastatic disease [2] for whom radical thoracic
radiotherapy is frequently part of treatment. The NSCLC
Collaborative Group meta-analysis [3] showed that sequential
cisplatin-based chemotherapy given in addition to radical
radiotherapy prolonged survival in patients with locally
advanced NSCLC. However, the prognosis for these patients
remained poor with a 3-year survival rate of approximately
14%. Cytotoxic agents used as radiosensitisers given at the
same time as radiotherapy have been evaluated against
radiotherapy alone in several randomised trials [4–14].
A primary aim of this combined approach was to improve
survival by increasing loco-regional control, while the
sequential use of chemotherapy has been......

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Title: Concomitant Radio-Chemotherapy Based On Platin
Approximate Word Count: 5905
Approximate Pages: 24 (250 words per double-spaced page)

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