Three Toronto scientists have developed an organ

transplant procedure that could, among its many

benefits, reverse diabetes. The procedure was

developed by Bernard Leibel, Julio Martin and

Walter Zingg at the University of Toronto and the

Hospital for Sick Children. The story of their work

began in 1978, when they delved into research

which had never before been tried. They wanted

to determine if the success rate of organ

transplants would increase if the recipient was

injected with minute amounts of organ tissue prior

to the transplant. The intention was to adapt the

recipient to the transplanted tissue and thereby

raise the threshold of rejection. In the case of the

diabetes experiment, this meant injecting rats with

pancreatic tissue before transplanting islets of

Langerhans, small clusters of cells scattered

throughout the pancreas which produce insulin,

glucagon, and somatostatin. In their first

experiment, outbred Wistar rats were injected

with increasing......

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Title: Transplants And Diabetes
Approximate Word Count: 364
Approximate Pages: 2 (250 words per double-spaced page)

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