Of all gynecologic malignancies, ovarian cancer continues to have the
highest mortality and is the most difficult to diagnose. In the United States
female population, ovarian cancer ranks fifth in absolute mortality among
cancer related deaths (13,000/yr). In most reported cases, ovarian cancer,
when first diagnosed is in stages III or IV in about 60 to 70% of patients
which further complicates treatment of the disease (Barber, 3).

Early detection in ovarian cancer is hampered by the lack of appropriate
tumor markers and clinically, most patients fail to develop significant
symptoms until they reach advanced stage disease. The characteristics
of ovarian cancer have been studied in primary tumors and in established
ovarian tumor cell lines which provide a reproducible source of tumor material.
Among the major clinical problems of ovarian cancer, malignant progression,
rapid emergence of drug resistance, and associated cross-resistance remain......

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Title: Ovarian Cancer
Approximate Word Count: 548
Approximate Pages: 3 (250 words per double-spaced page)

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