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By examining where and when genes are expressed in a cell or organism, one can acquire valuable hints to its function, for genes compile the genetic make-up of an organism and exploring the function of genes is helping to uncover the complexity of ourselves and of other forms of life (1). Significant developments have been made in gene monitoring techniques specifically in DNA microarrays which only very recently revolutionized genome expression analysis (1).
Despite continuous improvements and modification to the technique, DNA microarrays are still no more than a glass microscope slide studded with individual immobile nucleotide fragments (1, 2). The fundamentals of DNA microarrays are set on complementary base-pairing (3), and because the exact sequence and position of every segment on the slide is known, each serves as a probe for a specific gene (1).
The two main microarray systems are spotted DNA and oligonucleotide arrays (4); there are others with various difference...
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Title: DNA Microarrays
Approximate word count: 1017
Approximate pages: 5 (250 words per double-spaced page)
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DNA Microarrays. By ... Science 1997; 278:680-686 3. Brown P, Botstein D. Exploring
the new world of the genome with DNA microarrays. Nature ...
... Economic Considerations DNA microarrays were originally introduced in the late 1980s,
and they are becoming an increasingly common tool used by genomic ...
... DNAchips are the DNA microarrays, which are the orderly arrangements of DNA samples
fabricated by high-speed robotics on glass nylon or gold substrate. ...
... published a review in 2001 of a variety of new genome comparison techniques including;
Bioinformatic methods, DNA microarrays and Suppressive Subtractive ...
... In July 1999, Silicon Genetics launched GenEx, a public Internet database for
gene-expression data from microarrays, DNA chips and related technologies. ...

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